Qi is defined as a kind of subtle substance in the body with strong vitality and operation by the traditional Chinese medicine (TCM). Qi is so obscure as difficult to communicate with modern science. Based on the exploration of philosophy of Buddhism, Taoism and the scientific definition regarding matter, we assume the human qi is the intermediate conduction between spirit and body. The conduction is intangible but embodies ontological vitality and information from the spirit, and may be interpreted as the "vitality energy" in scientific definition of qi in up-to-date science. Hence the TCM therapy trends to energy treatment with information through channels, which tends to the essence of enanthrope; on the contrary, the western medicine materialistic treatment seems to alleviate the symptoms of illness. Through the empathic nature of the energy, it can clarifie the empty results of anatomy to qi. The new interpretation of qi may promote the modernizations of TCM.