Indriya is an important concept of early Buddhism. The early Buddhist literature has a more detailed description, and there are many studies in the academic circle. Based on the current academic achievements, according to the early Buddhist scriptures, and on the basis of summarizing the sememes of indriya and their relations, this paper focuses on the theoretical and practical significance of the establishment of this concept. Its theoretical significance is as follows: it refers to the ability possessed by life phenomenon; it clarifies the extreme and negative significance of life phenomenon; it explains the fundamental reason and internal power of reincarnation and liberation; it is the leading force of the trend of life phenomenon. Its practical significance is: to establish a correct outlook on life; to establish a correct outlook on practice from the the beginning of precepts; to affirm the positive significance of life and to carry out practice aimed at liberation. Indriya‟s theory shows that the living body has the ability to extricate itself, and it is in the saṃsāra because of the covering of ignorance. To achieve liberation, we should give full play to the positive force in the body of life, curb its negative force, get rid of ignorance, and carry out practice under the guidance of correct theory.