Pu-An Zhou (the Incantation of Monk Pu-An) can be traced back to the time earlier than Monk Pu-An. The guqin score of Pu-An Zhou was likely composed by Monk Pu-An and he passed it down because he present guqin score of Pu-An Zhou can only date back to the Ming Dynasty. In the guqin song of Pu-An Zhou, the lyric of the first sentence starts with the sound ka , and the sounds ca, ṭa, ta, and pa appear in the beginning of the following sentences. These are the five basic consonants in Siddhaṃ (a written form of Sanskrit). Pu-An Zhou has a simple structure to follow. Thus, it served as a chant for people to learn Siddhaṃ. The present study investigates the Siddhaṃ sounds of Pu-An Zhou. Four different versions of Pu-An Zhou are compared: Puan Zushi Shenzhou in Zhu Jing Risong Jiyao , Shi Tan Zhang in San Jiao Tong Sheng and Wu Zhi Zhai Qinpu, and Shi Tan Zhenyan in Xitan Jingchuan. In Shi Tan Zhenyan, Ranjana script appears next to Chinese characters. Singing the dhāraṇī (ritual speech or mantra) in Pu-An Zhou in the language of Sanskrit can produce a great energy which allows one to resonate with the universe. The effect is quite amazing. The pronunciation of Siddhaṃ in this paper was instructed by Shi Yiji the Acarya, and the guqin score based on Shi Tan Zhang in Wu Zhi Zhai Qinpu was reconstructed and sung in Sanskrit.