In the process of international communication and digital protection of ""Dunhuang Art"", this paper takes Dunhuang Research Institute as an example how to open up and use its independent collection, establish a digital database, cooperate with Tencent and other cutting-edge technology brands for diversified digital re-creation, form a new and radiating multi-media platform, and realize Dunhuang art derivatives and series projects for cultural communication and mass consumption. The Mogao Grottoes in Dunhuang have transformed from a cultural symbol with regional limitations into a cultural economic industrial body with all-round experience and consumption, and gradually formed an influential cultural heritage symbol all over the world. By analyzing and studying the protection work with copying and restoration as the main body in the early stage of the establishment of Dunhuang Research Institute, it will be orderly and open to the application of innovative digital technology to form a digital resource library of cultural heritage, cooperate with Tencent and Huawei in the field of exhibition and derivative development, and explore how to rely on ""Dunhuang Art"" as the main body of cultural industry by analyzing cases ""Open innovation"" theory, taking the development of science and technology as an opportunity, through resource cooperation, opening and control, constantly negotiate in the process, and finally achieve win-win results.