This dissertation mainly investigates the relation between the meanings between Non-self and Emptiness. It is discussed four parts. The first part focuses on the thought of Non-self in the Saṃyuktāgama and the Abhi-dharmakośabhāsya. The main discussion is based on three individual statements(論述). The three statements are all depicted with the core of Dependent Arising (緣起). Non-self is manifested by discussing the three statements. The second part researches Tsongkhapa’s thought of Non-self based on the madhyama-purusa path of the Lamrim Chenmo. In this part, the interactive relation of Non-self be-tween the madhyamapurusa path and the uttamapurusa path, is also explained. The third part investigates vipaśyanā of the uttamapurusa path, which is mentioned in Tsongkhapa’s works ( Lamrim Chenmo). This part contains the definition of vipaśya-nā, the classification of vipaśyanā, and the qualifications of learning vipaśyanā. The methods of learning emptiness thus is realized. The fourth part is mainly devoted to analyze the statements of Emptiness on the Lamrim Chenmo and the Middle stages of the path of enlightenment. Through them, the peculi-arities and characteristics of emptiness, which are from Tsongkhapa’s idea of Road se-quential, are pointed out. Then discusses the thought of Non-self and Emptiness in the Saṃyuktāgama and the Abhidharmakośabhāsya, in order to realize if the development mentioned above has the same or different viewpoints. Finally, to summarize how the arguments of emptiness on the uttamapurusa path development deeply on the basis of the thought of Non-self on the madhyamapurusa path. The mainly methodology of this dissertation are literature review and ideology research. By using the research method of literature review to understand the meaning of words in the Saṃyuktāgama, the Abhidharmakośabhāsya, and the Lamrim Chenmo. On the base of the understanding, continuously to analyze and elaborate the thought of Non-self and Emptiness in the Saṃyuktāgama, the Abhidharmakośabhāsya, and the Lamrim Chenmo.