Human being has been trying to explore the issue of life and death from different point of view since ancient times. However, there is no satisfactory answer of many problems of life and death so far even if there are lots of related studies of this issue during the past century. The main connotation of Buddha dharma is to define the issue of life and death, and this study which focuses on the life and death ideology of Tsongkhapa’s “The Great Treatise on the Stages of the Path to Enlightenment” probes the enlightenment of the Buddha Dharma on life and death. Tsongkhapa is the founder of Gelug Sect of Tibetan Buddhism, and also Inherits directly from Buddha’s teaching. Then, he wrote books, taught apprentices, constructed the temples, formed the association of education and held grand Buddhist assembly. To Tibetan Buddhism, Tsongkhapa is the one who flourish the culture of Buddhism and weed out abuse of the superstition. “The Great Treatise on the Stages of the Path to Enlightenment” is Tsongkhapa’s most important accomplishment, which is rich in theory to teaching human how to identify and classify the different of death of human; As well, this is the complete textbook for ordinary person to become a Buddha. This book adopts “The Three Types of Persons” to summarize different ordinary person's problems of life and death and their purpose of life. This book also combs out and shows beings the Buddhist practice ways to achieve goals by solving problems. Since The Persons of Small Capacity dreads the terrible consequences after death because of corrupted and depravity, this book guides beings how to take refuge successfully to achieve the blessedness after understand karma and samsara. Then, further being The Persons of Medium Capacity after making effort at meditation, person will realize even if in happiness, it is difficult to run away samsara or the reincarnation of bitter. It also means that beings should learn the theory of liberation and the theory of karma for raising the determination of escaping samsara. Finally, it is cruel to see suffering of all sentient beings, so the goal of life is not only to penetrate deeply the Buddhism, but also to purify beings. As well, to expand the pattern of life into the practice of The Persons of Great Capacity is essential. The main idea of “The Great Treatise on the Stages of the Path to Enlightenment” is becoming Buddha by step by step. This book shows beings how to accomplish three main Buddhist practices - “The Three Types of Persons” when they are on the process of cultivation, and also to overcome the death to achieve the completeness of live. “The Great Treatise on the Stages of the Path to Enlightenment” summarizes various life issues and proposes solutions; it provides a meaningful reference to contemporary life and death value at the same time.