The philosophers before Kant focused on the observation of the law of causality, while Hume, the skeptic, understood natural causality in empirical psychology, especially in a customary way. He confuses natural causality with humanistic causality. The foundation of learning is based on the law of happiness, and moral judgment comes from moral emotions. Kant took Hume 's revelation as a Copernican Revolution in《The Critique of Pure Reason》and further abandoned the empirical psychology. Before the establishment of the natural sciences, he introduced a transcendental Philosophy to explain how causal relationships are possible. Understanding rebuilds the general effect of knowledge and further establishes the ethical basis of its practice with《The Criticism of Practical Reason》.The ontology of Buddhism advocates that the subject of samsara: Tathāgatagarbha(ālaya-vijñāna) as the basis of the causality of the phenomenal world, the six channels of samsara and the transcendence of samsara. Therefore, knowing the origin of causality also proves the establishment of causality. In addition to stating the factual cause and effect of the universe 's life phenomena, Buddhist causal discourse has a strong humanistic value orientation and provides a solid platform for ethics, which is both reality(is) and can be pushed as it should(ought to be). This paper helps people to make judgments and choose the basis of the comparison between Eastern and Western philosophical causality.