Based on the religious characteristics of Taoism itself and its understanding of the universe and life, Taoism has its own unique view of life and body under the traditional ideological system of the unity of nature and man. Therefore, the understanding and treatment of epidemic diseases are also unique. The theological interpretation of the idea of the unity of nature and man is religious and humanistic care. This article is based on the Taoist view of life in the universe, which is the unity of nature and man, the interaction between nature and man, and the isomorphism of nature and man as the core. With the text of Nei Jing, it explores the theoretical basis and methods of disease prediction in the Wu yun liu qi, and sorts out the predictions of epidemics. The content and the Taoist cultural connotation in the plague treatment method, and finally the humanistic care connotation in it.