This dissertation focuses on mental and physical transformation through Buddhist meditation. By clarifying different layers of worldviews and by deconstructing the mind-body structure and relationship, this dissertation aims to provide a way for understanding how it can be possible to achieve a highly malleable mind-body state described in Buddhist scriptures. Preliminarily, Buddhist teachings provide a way to be reborn in a better life. Ultimately, Buddhism guides sentient beings and practitioners toward liberation and enlightenment. All these practices involve various degrees of mental and physical transformation, a core subject in Buddhist teachings. A well-constructed mechanism therein would ensure that Buddhist teachings can be better interpreted and understood in their original context. The present study begins with the key concepts to map out the theoretical terrain across a specific subject of mental and physical transformation in the Buddhist context, especially several literal passages drawn from the Śrāmaṇyaphala-sūtra. Concerning mental and physical transformation, different layers might involve varying principles, and at least two layers can be distinguished. The layer of transformation related to classical physics inquires into the transformation confined to current mind-body structure. The layer of transformation related to quantum physics is not restricted to the given mind-body binding. Similarly, under classical physics, the cognitive and spiritual absorption through meditative practices can transform the mind and body from being the outcome of the past and the environment to comparatively high elasticity and the ability to exert self-control. In quantum physics, from the perspective of conditioned co-arising, the mind and body can be deconstructed as a conglomeration of temporary related factors, devoid of any substance or an essence. In the same vein, the phenomenal world can be regarded as temporal aggregates universally shared in the message field of dharma-dhātu. Mind power with meditation facilitates the process of drastically transforming the body to perform extraordinary wonders and to penetrate into the message field of dharma-dhātu. This is the embodiment of mental and physical transformation by surpassing the ordinary mind-body event. The first chapter introduces the main idea, value, and methodology of this dissertation. In the second chapter, the various concepts and ideas of transformation in Buddhist scriptures are analyzed and organized in order to provide a foundation of further study in this dissertation. The third chapter focuses on the meditations closely related to transformation. Following an analysis of the two key concepts --transformation and meditation -- the Śrāmaṇyaphala-sūtra was consulted in chapter four as an exemplar for illustrating sequential transformation and progressive meditation. In chapter five, the purpose of a clarification of various layers and aspects of worldviews is to address difficulties with unsuitable worldviews encountered in u