Dependent Origination is not only the ultimate truth of life and universe enlighten by Buddha, but also his main teaching to lead disciples practice rightly. However, the profound co-arising is very difficult to understand. Different views, understandings and practice lead to different interpretation and application. Exploring Buddha's authentic thinking on Dependent Origination is the determinant route to reach the enlightenment as Buddha's. This study applies the views of system dynamics to the thinking of Dependent Origination proposed by Yin-Shun. The human-based dharma system with three levels including "body-mind relationships","social relationship" and "natural relationship" is introduced to discuss the meaning and characteristics of Dependent Origination. The dialog between system dynamics and dependent originaiton is made to bring more useful understandings on Dependent Origination.