Menopause is the natural transitional period of life, and "a period of change in health system", which will lead to many physical and psychological symptoms, so more attention should be paid to the health problems during this period. This study investigated the effectiveness of Buddhist-music treatment on the climacteric symptoms and the impact on the meridian system of Perimenopausal women. We adopted the Quasi-Experimental research design for our study, using convenience sampling as the screening method for eligible cases. The experimental group (n = 42) received intervention of Buddhist Music 3 times per month, from 19:30-21:30 of about 2 hours duration each time, for a total of 12 times. The control group (n = 30) did not receive any intervention. Subjects with the total number of study times <=9 was assgined to subgroup A(n=20), while those with the total number of study times >9 was assigned to subgroup B(n=22). The effect on the climacteric symptoms and on the meridian system before and after the intervention were evaluated, and the results served as a basis of the effectiveness of the measures. After the intervention of Buddhist Music treatment, there were a stastiscally significant difference in the average meridial values and menopause distress scale Our study showed Buddhist music study may help to improve the menopausal symptoms and the actual situation of the Meridians and body organs.