High Quality Content by WIKIPEDIA articles! The Twelve Nid?nas (Pali/Sanskrit nid?na "cause, foundation, source or origin") are the best-known application of the Buddhist concept of prat?tyasamutp?da (dependent origination), identifying the origins of suffering to be in craving and ignorance. The Twelve Nid?nas are employed in the analysis of phenomena according to the principle of Prat?tyasamutp?da. The aim of the Twelve Nid?nas analysis is to reveal the origins of phenomena, and the feedback loop of conditioning and causation that leads to suffering in current and future lives.