Buddhist sutra “Nikaya” believes that every single life started with birth, go through the old, disease, and at the end come to the death. No matter rich or poor, wise or foolish would inevitably go through into the phenomenon. Since it is so, what do we cultivate for?People are looking for the ways to improve the mental state, and the courage or wisdom to face the hard moments. But the ways of improving the mental state, or the courage, wisdom to face the hard moments are varied with each individual. Zhuang Zi’s philosophy shows superior wisdom. We can realize that when others took care about personal reputation, wealth, position or knowledge power, Zhuang Zi could be unconcerned about them, and depicted wonderful spiritual freedom. Some people think that Zhuan Zi’s mental liberation is similar to Buddhist philosophy. Buddhists believe that there is not anything can represent “One Self”, therefore there is nothing to persist in. Since no persisting in anything, Buddhists could reach the spiritual peace and quiet. Some people confuse these two different philosophies and think they are similar. But it is two entirely different things after all, we just can’t deny, the two belong to different ideological systems. In this research I would like to find out the similarities between them in the fatal concept. Knowing that this topic is quite huge, after choosing and selection, I would discuss the fatal concept from life and death, morality, good fortune and misfortune, fame, human body’s concept. Hope to find out why people always compare theses two ideological systems.