As one of the main sources in regards to the interpretation and development of Chinese Buddhist studies, issues and topics that can be further probed in are considerably heterogeneous. With only Master Yin Shun’s interpretation and discussion on Mahāprajñāpāramitopadeśa (Da-zhi-du-lun, hereafter abbreviated as DZDL) as our main core of study, and as an example of study on how to comprehend and interpret DZDL within the history of the development of Chinese Buddhism.With this to indicate that the comprehension and interpretation of DZDL of Yin Shun can be exploited through two types of perspectives, i.e the Methodology and Philosophical stances. In regards to the Methodology, in his works of “The Notes for DZDL”, Yin Shun selected important concepts from DZDL, either in the forms of clauses and subclauses or abstraction of important sentences from the text. They seem to be in the form of notes, but within I caught sight of his own interpretation and comprehension concealed behind this form of notes. Again, though his interpretation and citation of DZDL were scattered in his vast works, they can be classified into two types of interpretation, i.e. the Buddhist Philosophy and Buddhist History. The interactive usage of these two types of interpretation shaped the principal axis of the Methodology of interpretation of Yin Shun on DZDL. Among embodied the clarification of Buddhist fundamental concepts, the mediation and viewpoints on the critical and systematic classification of the positions of Buddhist schools. In terms of the Philosophical stance, on the foundation of his Methodology, beside the revealing of his comprehension, weighting and judging on Buddhist Philosophy, Yin Shun’s interpretation on DZDL also exhibited his philosophical points. This standpoint has to be recalled back to the understanding and comprehension of the philosophical fundamental problems of Indian Mādhyamaka philosophy. This paper shows that under the Methodology stance, not only Yin Shun reconstructed the historical and thought scene, his persistence in the literary content, and he also placed high value on the theoretical connotation of Indian Mādhyamaka philosophy. With this to response and refute specifically on contemporary interpretations of DZDL. Thus, the duo-interpretation path of Buddhist Philosophy and Buddhist History can aid us in making the most out of Yin Shun’s comprehension and interpretation of DZDL, and also present his Methodology and philosophical stances.