In the current dissertation “A Study of Bodhisattva’s Practice in the Gaṇḍavyūha Chapter of Avataṃsaka” the primary textual source will be the 80-fascicle Avataṃsaka. In the course of study, I shall also justify my arguments against the corresponding Chapter of the 60-fascicle Avataṃsaka, the teaching of the 40-fascicle Avataṃsaka. I believe such detailed investigation will provide an accurate interpretation of the text’s doctrine and broaden our understanding of a bodhisattva’s practice according to the Gaṇḍavyūha. I hope it will also make a significant academic contribution. The current investigation will be conducted in the following three steps. First, I study the place of origin and compilation of the Gaṇḍavyūha, its transmission to China, the content, and organization. Secondly, I scrutinize how the main Huāyán tenets appear and support the scripture’s teaching of a bodhisattva’s practice. Thirdly, I analyze features of a bodhisattva’s practice according to the Gaṇḍavyūha, and how this practice enables one to penetrate the realm of reality. I will also expound the way the doctrine is conveyed in the scripture. Its narrative elucidates teachings of the fifty-three spiritual masters; each assembly has a distinctive liberation gate. In this way, the perfect interpenetration and unfolding of bodhisattva’s practices at different stages exhibit relationship between the doctrine of the single vehicle and the essence-and-function of the dharma-gates. In addition, I shall discuss Sudhana’s personality traits and his spirit of pursuing the Dharma; how the sūtra through Sudhana’s character reveals the ten pāramitās as the cause, and myriad deeds as the function. The myriad deeds are the liberating activities peculiar to bodhisattvas; they are a manifestation of the spirit which the spiritual masters embody. It is because the essence and function of the Dharma gates extends beyond worldly pursuits. Further, I shall discuss how the spirit of people involved, and the peculiarity of locations where the teachings take place serve as similes which disclose the mutual relationship between one seeking the teaching and a master expounding the Dharma. Moreover, a detailed study of the teaching of the five great bodhisattvas among the fifty-three Sudhana’s spiritual masters suggests that the corresponding five dharma-gates encompass entirely all the virtuous qualities of the other masters and their instructions. Therefore, in the current study I particularly elucidate the dharma-gates conveyed by these great bodhisattvas. Finally, in order to reveal the teaching’s relevance to the practice of the Humanistic Buddhism, I will specially discuss Sudhana’s spiritual quest for perfect buddhahood in the human realm. Indeed, the teaching of the Gaṇḍavyūha can be considered as a model of practices leading to buddhahood performed within the human destiny. In order to penetrate into the realm of reality, the most important is the spirit, which encompasses giving rise to the mind of bodhi and performing of bodhisattva practices. Moreover, it is peculiar to the Gaṇḍavyūha that among bodhisattvas’ deeds leading to liberation of sentient beings there are agreeable and disagreeable methods, all kinds of samādhis and skillful means which are employed t