Bru sha was an important state in the western Zhang Zhung and was split into big Bru sha and small Bru sha in the eighth century under the control of Tubo. In history,Tibetan Bon religion was very popular in this region where the second largest Lama family of Bon religion,Zhu’s family originated. After Zhu’s family migrated from Bru sha to Ali and Shigatse in Tibet,it became the backbone power of religious reform in the late period of Bon religion. Besides,the family had a close relation with Tibetan Buddhism,for the Fifth Panchen and the Eighth Panchen were both from this family. The complicated relationship between Bru sha,Zhu’s family,the Bon religion and Tibetan Buddhism has provided a new academic angle for us to fully understand the ancient Tibetan history represented by Zhang Zhung and Tubo,objectively analyze the relationship between Buddhism and Bon religion,and make a comparative study of the policies to govern Tibet by the central governments in the past dynasties. Meanwhile,it also reflects the historical trend of integrated development of different ethnic groups linked by religious culture in border areas of ancient China.