This essay offers some considerations on the value of the Chalcedonian paradigm as a resource for interreligious systematic speculation. The author's analysis focuses on the Christology of Maximos the Confessor and the Buddhological speculations of the Tibetan thinker and monastic reformer Tsong kha pa. The paper explores the points of contact, as well as the differences, between these two approaches. In conclusion the author offers some constructive considerations as to the shape of a contextual Tibetan Christology that would appropriate the conceptual heritage of the local philosophy and culture. He also suggests how familiarity with Tsong kha pa's epistemological horizon may be of help in gaining a better appreciation of the Christological paradigm behind Maximos's vision.