This study is aimed to explore the self-healing power of meditation and its effects on stress, depression, anxiety and well-being. The researcher reviews the literature related to mediation and proposes the concept of the self-healing power. Then, the hypotheses and measurement scales are developed according to the study aim. The data of 514 cases used in this study consist of 251 cases in the meditation group that practice meditation and 263 cases in the non-meditation group that do not practice meditation.The results of explanatory factor analysis show four major factors for the self-healing power, 1. mindfulness, 2. kindness, 3. stability, and 4. awareness. The major results are summarized as follows:（1）The cases in the meditation group have higher scales of self-healing power, lower scales of stress, lower scales of depression, and higher scales of well-being than those in the non-meditation group.（2）The structural equation modeling （SEM） for the self-healing power, stress, depression, anxiety and well-being fit in the collected data. The path analysis shows the following results. The self-healing power can reduce the stress and increase the well-being. Through the reduction of stress, the self-healing power can reduce the depression and increase the well-being. The researcher proposes suggestions based on the above results that can be used for professional consulting, medical institution, human resource units and future researches.
