This essay tries to resolve an important problem of Cartesian dualistic interactionism, which is that if mind and body are two distinct and independent substances in their nature, how the interaction between them is possible, with Buddhist three teachings : ＂person is made up of five aggregates (pañca-skandha) given patītyasamutpāda,＂ ＂the mind-body is non-duality,＂ and most importantly ＂the five aggregates are emptiness (śūnyatā) based on the Prañjā Pāramitā Heart Sutra.＂ Besides, we will also touch two relevant issues of Buddhism. When most of the Buddhist scholars discuss the mind-body problem, they tend to focus on the relation between mind and body rather than two fundamental questions: ＂What is the nature of non-duality of mind and body?＂and ＂How is it possible for mind and body to have a relation?＂ The answer for the former is the basis for the latter, and the latter bears a weak sign (or meaning) of the problem of Cartesian dualistic interactionism. For if there is not a common nature (or ground) of mind and body, it is problematic to state that there is a relation between them. Therefore, we employ the teaching that the five aggregates are emptiness in Prañjā Pāramitā Heart Sutra to resolve the problem of Cartesian dualistic interactionism and to clarify the Buddhist two fundamental questions.
