The underlying mechanisms of life and death have been elusive despite advances in science and technology. However, Buddhist teachings offer some fresh insights into life and death, such as the understanding gained through reflections on conditioned co-arising, emptiness, nonduality, and illusion. Aiming at constructing a Buddhist philosophy of space-time, this paper attempts to further explore the process of life-and-death as taught especially in the Āgama-sūtras and Prajñāpāramitā-sūtras. Some of the advantages of applying a space-time approach to the process of life-and-death including: (1) Life and death can be viewed from a worldview of space-time, which functions as a unified foundation to cognize the world. (2) In terms of a philosophy of time as an ongoing process and space as an ever-expanding horizon, life and death can be viewed as a process or network utterly devoid of beginning, middle, or end. (3) The reality of life and death can be realized as neither life nor death through an understanding of the reality of space-time as neither the past nor the future nor the present. (4) Such insights into life and death help one not only recognize the problems in the world, but also come up with possible solutions.